Reparative histogenesis of bone tissue in femoral fractures in rats using biocomposite material along with immunocorrection

The paper studies the effect of RVI biocomposite material belonging to group osteoplastic materials, RV-2 immunomodulator – a synthetic dipeptide inducing an immunocorrective effect, and combinations these drugs on reparative histogenesis bone tissue in femoral fractures rats. It was found that remodeling primary callus into secondary one fracture studied animals diverse nature. This process most pronounced where components were used complex, i.e. defect filled with during surgery, as well injected intramuscularly rats at dose 10 mcg per 1 kg live weight for five days, starting immediately after surgery. Well-formed coarse-fibrous connective recorded this group. stained more intensely which indicates denser arrangement fibers callus. Focal cartilage spanning fragments observed within At periphery site cartilaginous subjected endochondral ossification replacement by trabeculae elements lamellar having haversian canals center. inter-girdle spaces myeloid marrow forming tissue. Markedly proliferated osteoblasts visible cambial layer periosteum. ratio increased up (60.21 ± 2.62)%, significantly exceeded same indicator control all experimental groups. low content high indicated active osteogenesis processes regeneration comparison other